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Tesis Doctorales de la Universidad de Alcalá
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EL DESARROLLO POSTEMBRIONARIO DEL SISTEMA NERVIOSO CENTRAL DE MACROSTOMUM LIGNANO (PLATYELMINTHES, RHABDITOPHORA)
Autor/aMiguel Bonet, Maria del Mar de
DepartamentoBiomedicina y Biotecnología
Director/aNoreña Janssen, Carolina Julia
Fecha de defensa08/03/2022
CalificaciónSobresaliente Cum Laude
ProgramaBiología Funcional y Biotecnología (RD 99/2011)
Mención internacionalSi
ResumenPlatyhelminthes, commonly known as flatworms, are a phylum of animals that includes free-living species (such as turbellarians or planarians) and important parasites for medicine or veterinary sciences (flukes, tapeworms or monogeneans). In research, the marine microturbellarian Macrostomum lignano (Platyhelminthes, Rhabditophora) is an emerging laboratory model. It is easy to cultivate or handle, it has a sequenced genome, and multiple molecular tools are available for its study. M. lignano is a basal bilaterian organism with a true Central Nervous System. It consists of a compartmentalized brain and two main lateral nerve cords. This study presents, for the first time, the types, ultrastructure and three-dimensional models of the cells that form the frontal glandular complex of the species: the sensory receptors that connect anteriorly with the brain and the glands that traverse it. Two new glands are reported, as well as a 3D model of the ciliary photoreceptors, the situation of the sensory receptors cell bodies in the cerebral cortex and the place where its upper limit is. The ultrastructure of the neurons in the cerebral cortex; their synapses; brain growth; and the neurogenesis processes that take place during post-embryonic development from stem cells called neoblasts are also described.